Ensemble Effect , Not Entourage Effect

The Ensemble Effect VS The Entourage Effect

The Ensemble Effect is the preferred definition for what is currently known as the Entourage Effect. This is an Article to support the reasons to convert to the Ensemble Effect for sake of definition.

Many people are lead to believe that CBD is the most important cannabinoid and that they do not need any others. This article is to help explain why, and why the grammatical change makes a world of difference.

Ensemble Effect - Not the Entourage Effect. Why it's called the Ensemble Effect.

Heartland Hemp Inc.’s Definition of Ensemble Effect

The Ensemble Effect describes when multiple components come together, such as an orchestra.

When regarding Hemp and Cannabis the Ensemble Effect refers primarily to a full or broad spectrum of cannabinoids and phytocannabinoids are that equally important within the same proprietary mixture.

First a spectrum including Cannabidiol (CBD) and Tetrahydrocannabinol (THC), while retaining as much of the CBG (Cannabigerol), CBN (Cannabinol), CBC (Cannabichromene), THCV (Tetrahydrocannabivarin), and many other currently unlisted phytocannabinoids that are obtained from the plants.

The carrier oil involved should react and mix well with cannabinoids. Carriers  such as hemp oil,  coconut oil or sunflower oil to name a few are common and have their own benefits in delivery.

The final piece to the ensemble effect includes the presence of terpenes (or terpenoids), which are currently still being closely studied, although many benefits have already begun to be associated with them.

With these equally important components, and through a detailed and clean process, you create the ensemble effect in full.

The Ensemble Effect ensures the most rapid delivery in the body when the most effective cannabinoids, phytocannabinoids, terpenoids, and oil mix together. This mixture allows each of their parts to  perform their tasks at peak performance thanks to their ability to work harmoniously.

Understanding Ensemble V.S Entourage Effect

Heartland Hemp Inc. spent considerable time on reviewing these definitions, statements, and published medical studies in regards to the endocannabinoid system, the enzymatic process of metabolizing cannabinoids, and dictionary definitions in order to compare the definitions.

Below we cover the history of the terminology, and provide supporting information.

True Definitions of Ensemble and Entourage

Ensemble:

en·sem·ble

[änˈsämbəl]

NOUN

  1. a group of musicians, actors, or dancers who perform together.”a Bulgarian folk ensemble”synonyms: group · band · orchestra · combo · company · troupe ·
    • a scene or passage written for performance by a whole cast, choir, or group of instruments.
    • the coordination between performers executing an ensemble passage.”a high level of tuning and ensemble is guaranteed”
  2. a group of items viewed as a whole rather than individually.”the buildings in the square present a charming provincial ensemble”synonyms: whole · whole thing · entity · unit · unity · body · piece ·

Entourage:

en·tou·rage[ˌänto͝oˈräZH]NOUN

  1. a group of people attending or surrounding an important person.”an entourage of bodyguards”synonyms: retinue · escort · company · cortège · train · suite · court · staff · bodyguard· attendants · companions · followers · retainers · members of court ·

Born June 24, 1928, Dr. Lester Grinspoon is an Associate Professor Emeritus of Psychiatry at Harvard Medical School. Dr. Grinspoon was the senior psychiatrist at the Massachusetts Mental Health Center in Boston for 40 years. Dr. Grinspoon is a fellow of the American Association for the Advancement of Science and the American Psychiatric Association.

He was founding editor of The American Psychiatric Association Annual Review and Harvard Mental Health Letter. Grinspoon was editor of Harvard Mental Health Letter for fifteen years.

Dr. Lester Grinspoon

Ensemble Effect as Defined by Dr. Lester Grinspoon

It was in 2016 that Dr. Grinspoon interviewed with HighTimes Magazine  where he told them that he preferred the term “Therapeutic Ensemble” which we too agree with.

In his quote here, he goes on to say:

I think that the ensemble is a better idea than entourage, because the word  ‘entourage’ implies that one item moving in this direction – and it has company,”

“And it is the item that is responsible for that activity, and the others just go along. That’s ‘entourage’.”

“The word ‘ensemble’ means that these are the three things that are required for the best therapeutic effect, but you can manipulate the percentage of two of them. “

“The phyto-chemicals (phyto-cannabinoids), the terpenoids, they come with it, as long as it is derived from the from the bud, from the plant, and not from some oil where all phyto-chemicals (phyto-cannabinoids) have been distilled out.

As long as you are getting it from the bud you can manipulate by mixing strains.”

In this situation, Dr. Grinspoon is referring to Cannabis. This is applicable to Hemp as well.

For help with understanding the differences between Hemp and Cannabis, and also to see how Hemp and Cannabis are similar, read our article on The Differences Between Hemp and Cannabis.

The Explanation of The Entourage Effect on CNN by Dr. Mechoulam & Dr. Sanjay Gupta

Born October 23, 1969 Dr. Sanjay Gupta is an American neurosurgeon and medical reporter. He serves as associate chief of the neurosurgery service at Grady Memorial Hospital in Atlanta, Georgia, and as assistant professor of neurosurgery at the Emory University School of Medicine.

This article discusses his published paper on the Entourage Effect.

Dr. Sanjay Gupta

It was halfway through our long afternoon discussion that Mechoulam, now 83, pulled out a paper he had written in 1999, describing something known as “the entourage effect.”
Think of it like this: There are more than 480 natural components found within the cannabis plant, of which 66 have been classified as “cannabinoids.”

Those are chemicals unique to the plant, including delta-9-tetrahydrocannabinol and cannabidiol. There are, however, many more, including:

— Can-na-bi-ger-ols (CBG);
— Can-na-bi-chro-menes (CBC);
— other Can-na-bi-di-ols (CBD);
— other Te-tra-hy-dro-can-na-bi-nols (THC);
— Can-na-bi-nol (CBN) and can-na-bi-no-di-ol (CBDL);
— other cannabinoids (such as can-na-bi-cy-clol (CBL), can-na-biel-soin (CBE), can-na-bi-tri-ol (CBT) and other miscellaneous types).

Other constituents of the cannabis plant are: nitrogenous compounds (27 known), amino acids (18), proteins (3), glycoproteins (6), enzymes (2), sugars and related compounds (34), hydrocarbons (50), simple alcohols (7), aldehydes (13), ketones (13), simple acids (21), fatty acids (22), simple esters (12), lactones (1), steroids (11), terpenes (120), non-cannabinoid phenols (25), flavonoids (21), vitamins (1), pigments (2), and other elements (9).

The Entourage Effect As Written By Dr. Sanja Gupta

Don’t be discouraged! This will be broken down and explained, no need for fancy words within lengthy paragraphs here!

In the paper that Dr. Sanjay Gupta wrote, it’s first paragraph reads:

Te-tra-hy-dro-can-na-bi-nol (THC) has been the primary focus of cannabis research since 1964, when Raphael Mechoulam isolated and synthesized it.

More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia have been scientifically demonstrated.

Other phyto-cannabinoids, including te-tra-hy-dro-can-na-bi-va-rin(THCV), can-na-bi-ger-ol (CBG) and
can-na-bi-chro-mene(CBC), exert additional therapeutic effects.

Terpene Quick Overview

Innovative conventional plant breeding has yielded cannabis chemo-types expressing high titres of each component for future study. This review will explore another echelon of phyto-therapeutic agents, the cannabis terpenoids: limonene, myrcene, a-pinene, linalool, b-caryophyllene, caryophyllene oxide, nerolidol and phytol.

Terpenoids share a precursor with phytocannabinoids, and are all flavor and fragrance components common to human diets that have been designated Generally Recognized as Safe by the US Food and Drug
Administration and other regulatory agencies.

Terpenoids are quite potent, and affect animal and even human behavior when inhaled from ambient air at serum levels in the single digits ng·mL-1.

Terpene Health

They display unique therapeutic effects that may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts. Particular focus will be placed on phyto-cannabinoid-terpenoid interactions that could produce synergy with respect to treatment of pain, inflammation, depression, anxiety, addiction, epilepsy, cancer, fungal and bacterial infections (including methicillin-resistant Staphylococcus aureus).

Scientific evidence is presented for non-cannabinoid plant components as putative antidotes to intoxicating effects of
THC that could increase its therapeutic index. Methods for investigating entourage effects in future experiments will be
proposed.

Phyto-cannabinoid-terpenoid synergy, if proven, increases the likelihood that an extensive pipeline of new
therapeutic products is possible from this venerable plant.

While both descriptions hold an amount of viability too them, the Ensemble Effect is the best way to describe how the cannabinoids, phytocannabinoids, and terpenoids are reacting, acting, choreographing, and synchronizing to provide harmonious relief throughout the body. That is not to say that we disagree with Dr. Sanjay Gupta at all.

Understanding The Effect Itself Through Dr. Gupta

In this section of the article, you will be given the meaning of each section of the article, and then have that section of the article re-introduced to you with that explanation a little more fresh in your minds. Before we really dive in, it’s important we introduce Raphael Mechoulum.

Who is Raphael Mechoulam?

In his statements and in the CNN report, Raphael Mechoulum is referenced directly, as well as directly cited in the first paragraph of the Entourage Effect by Dr. Sanjay Gupta. 

Raphael Mechoulum

Born in 1930, Raphael Mechoulum is an Israeli organic chemist and professor of Medicinal Chemistry at the Hebrew University of Jerusalem in Israel.

Mechoulam is best known for his work (with Y. Gaoni) in the isolation, structure elucidation and total synthesis of Δ9-tetrahydrocannabinol, the main active principle of cannabis and for the isolation and the identification of the endogenous cannabinoids anandamide from the brain and 2-arachidonoyl glycerol (2-AG) from peripheral organs together with his students, postdocs and collaborators.

Raphael Mechoulum is an important man in the cannabis and hemp industry thanks to his achievements , where his most notable achievement was in isolating Tetrahydrocannabinol Delta 9 (Activated THC).

CBD, Cannabinoids, and Pharmacology

Dr. Gupta continues immediately into his next points with discussing the “synergism” between “cannabidiol” or CBD and their pharmacological (pharmacy or pharmaceutical / medical) practices involving cannabis. What he is saying here in plain English:

CBD works very well along side cannabis.

He goes on to say: Other phytocannabinoids including THCV, CBG, and CBN also show promise in there medical applications.

To read again with this explanation in mind:

More recently, the synergistic contributions of cannabidiol to cannabis pharmacology and analgesia
have been scientifically demonstrated. Other phytocannabinoids, including tetrahydrocannabivarin, cannabigerol and
cannabichromene, exert additional effects of therapeutic interest.

Terpenes or Terpenoids & Their Role

Terpenes or terpenoids are the “smells” and “flavors” of the cannabis plants as well as other plants, however most interestingly, these smells and flavors are tell-tale signs of what the plant may be able to do for you.

Dr. Gupta states that after many years of innovative plant breeding, different strains containing different phyto-therapeutic (natural plant therapy) properties, where such terpenes as Limonene (associated with gastrointestinal relief, anti-anxiety, and anti-depression) are being looked at in medical applications.

Terpenes have also been designated as safe by the US Food Drug Administration, so possession and use of terpenes is perfectly fine.

With this explanation, read it over again!

Innovative conventional plant breeding has yielded cannabis
chemo-types expressing high titres of each component for future study. This review will explore another echelon of phytotherapeutic agents, the cannabis terpenoids: limonene, myrcene, a-pinene, linalool, b-caryophyllene, caryophyllene oxide, nerolidol and phytol.

Terpenoids share a precursor with phytocannabinoids, and are all flavor and fragrance
components common to human diets that have been designated Generally Recognized as Safe by the US Food and Drug
Administration and other regulatory agencies.

Resources: